- Title
- Paucity of evidence for a relationship between long-chain omega-3 fatty acid intake and chronic obstructive pulmonary disease: a systematic review
- Creator
- Fulton, Ashley S.; Hill, Alison M.; Williams, Marie T.; Howe, Peter R. C.; Coates, Alison M.
- Relation
- Nutrition Reviews Vol. 73, Issue 9, p. 612-623
- Publisher Link
- http://dx.doi.org/10.1093/nutrit/nuv017
- Publisher
- Oxford University Press
- Resource Type
- journal article
- Date
- 2015
- Description
- Context: The anti-inflammatory activity of long-chain n-3 polyunsaturated fatty acids (PUFAs) has been established in several chronic inflammatory diseases but has yet to be demonstrated in inflammatory lung diseases such as chronic obstructive pulmonary disease (COPD). Objective: The aim of this systematic review was to investigate, using PRISMA guidelines, the relationship between the intake of long-chain n-3 PUFAs and the prevalence, severity, and health outcomes of COPD. Data Sources: Eight health databases and the World Health Organization's international clinical trial registry were searched for relevant studies. Study Selection: Experimental or observational studies that were published in English and that assessed long-chain n-3 PUFA intake (by determining habitual consumption and/or tissue levels) in adults with COPD were included. Data Extraction: Publication demographics, participant characteristics, type of intervention or exposure, long-chain n-3 PUFA intake, pulmonary function, COPD mortality, and COPD severity were independently extracted from each article by 2 authors using a prospectively designed data extraction tool. Data Synthesis: All 11 of the studies included in the review were observational. Approximately equal numbers of studies reported significant (n=6, 5 inverse) relationships or no significant relationships (n=5) between either consumption of long-chain n-3 PUFAs or levels of long-chain n-3 PUFAS in tissue and a COPD outcome. Conclusions: Current evidence of a relationship between long-chain n-3 PUFA intake and COPD is limited and conflicting, with studies having wide methodological variation. Registration number: PROSPERO 2013:CRD42013004085.
- Subject
- chronic obstructive pulmonary disease; COPD; long-chain n-3 fatty acid; LCn-3 PUFA; polyunsaturated fatty acid; systematic review
- Identifier
- http://hdl.handle.net/1959.13/1331348
- Identifier
- uon:26603
- Identifier
- ISSN:0029-6643
- Language
- eng
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